|
T15942 |
MK-7622
|
M1 receptor modulator |
AChR
|
|
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric. |
|
T81893 |
M1/M4 muscarinic agonist 2
|
|
|
|
Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1]. |
|
T9353 |
OXOMEMAZINE
|
|
AChR
,
Histamine Receptor
|
|
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... |
|
T7002 |
Trihexyphenidyl hydrochloride
|
Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride |
AChR
|
|
Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class. |
|
T23297 |
(S)-(+)-Dimethindene maleate
|
|
AChR
,
Histamine Receptor
|
|
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that inhibits muscarinic M1, M3, and M4 receptors. |
|
T80662 |
CDD0102 HCl
|
CDD0102A HCl |
AChR
|
|
CDD0102 HCl is a selective and potent M1 muscarinic receptor agonist for the treatment of Alzheimer's disease. |
|
T23071 |
Nitrocaramiphen hydrochloride
|
|
AChR
|
|
M1 muscarinic antagonist |
|
T68153 |
Tazomeline
|
|
AChR
|
|
Tazomeline is a muscarinic M1 receptor agonist with neuroprotective activity. |
|
T23508 |
VU 0255035
|
|
AChR
|
|
muscarinic M1 antagonist |
|
T22963 |
McN-A 343
|
|
AChR
|
|
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental ... |
|
T1542 |
Pirenzepine dihydrochloride
|
Pirenzepine HCl,Bisvanil,Tabe,LS519 |
AChR
|
|
Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion. |
|
T12531 |
PQCA
|
|
Others
,
AChR
|
|
PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity again... |
|
T20026 |
WEB-1868
|
WEB 1868,WEB1868 |
Others
|
|
WEB-1868 is one of the metabolites of nebracetam which is an agonist for human M1-muscarinic receptors. |
|
T8147 |
Solifenacin
|
YM905 free base |
AChR
|
|
Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively. |
|
T8224 |
VU0119498
|
|
AChR
|
|
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. |
|
T7780 |
Blarcamesine
|
AE-37,AVex-73 |
AChR
|
|
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. |
|
T12201 |
Nebracetam hydrochloride
|
WEB 1881 FU hydrochloride |
AChR
|
|
Nebracetam hydrochloride (WEB 1881 FU hydrochloride) is an agonist nootropic M1-muscarinic. Nebracetam hydrochloride induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 m... |
|
T8383 |
Cyclopentolate Hydrochloride
|
|
AChR
|
|
Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively. |
|
T60536 |
Terodiline
|
|
|
|
Terodiline is a Ca 2+ blocker and M1-selective muscarinic receptor (mAChR) antagonist with Kb of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodil... |
|
T1049 |
Oxybutynin chloride
|
Oxybutynin hydrochloride,Oxybutynin HCl |
Potassium Channel
,
AChR
|
|
Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. |
|
T6707 |
Tiotropium Bromide hydrate
|
BA-679 BR hydrate,BA 679BR |
AChR
|
|
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
|
T8219 |
VU0238441
|
|
AChR
|
|
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. |
|
T12489 |
Pimethixene
|
Calmixen,Pimetixene |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T0111 |
Solifenacin succinate
|
YM905 |
AChR
|
|
Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE. |
|
T2390 |
Cevimeline hydrochloride hemihydrate
|
|
AChR
|
|
Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
|
T0862 |
Diphenidol hydrochloride
|
Diphenidol HCl,Difenidol hydrochloride |
Sodium Channel
,
AChR
|
|
Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug. |
|
T1475 |
Fesoterodine fumarate
|
Toviaz,SPM 907 |
AChR
|
|
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
|
T23265 |
RS 67333 hydrochloride
|
RS 67333 (hydrochloride),RS 67333 HCl |
5-HT Receptor
|
|
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, inclu... |
|
T1460 |
Dicyclomine hydrochloride
|
|
AChR
|
|
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
|
T27961 |
LY593093
|
LY 593093,LY-593093 |
|
|
LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor. |
|
T25005 |
AF267
|
(±)AF 267,(±) AF 267,(±)-AF 267,AF 267,AF-267 |
|
|
AF267 is a M1 muscarinic agonist that works by restoring cognitive impairments. |
|
T23452 |
Telenzepine dihydrochloride
|
|
Others
|
|
muscarinic M1 receptor antagonist |
|
T26328 |
VU0455691
|
VU 0455691,VU-0455691 |
|
|
VU0455691 is a selective M1 Muscarinic Receptor Allosteric Modulators. |
|
T10731 |
CDD0102
|
CDD0102A |
AChR
|
|
CDD0102 is a potent agonist of M1 Muscarinic receptor. |
|
T26541 |
AC-42
|
|
|
|
AC-42 is an allosteric agonist of M1 muscarinic receptor. |
|
T29143 |
VU6004256
|
VU 6004256,VU-6004256 |
|
|
VU6004256 is a selective positive allosteric modulator (PAM) of muscarinic receptor M1. |
|
T23649 |
AF-710B
|
AF710B,AF 710B |
|
|
AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist. |
|
T23787 |
BGT1-IN-9
|
BGT1 IN 9,BGT1 inhibitor 9,BGT1IN9,BGT1-inhibitor-9 |
|
|
BGT1-IN-9 is an M1 muscarinic agonist. |
|
T14092 |
AC260584
|
|
Others
|
|
|
|
T24469 |
MIPS1455
|
MIPS-1455,MIPS 1455 |
|
|
MIPS1455 is a photoactivatable allosteric M1 muscarinic acetylcholine receptor ligand. |
|
T80183 |
Muscarinic toxin 7
|
|
|
|
Muscarinic toxin 7 (MT7) is a peptide exhibiting selective, noncompetitive antagonistic activity at the muscarinic M1 receptor [1]. |
|
T33949 |
PF-06764427
|
PF06764427 |
|
|
PF-06764427 is a selective positive allosteric modulator of azazindole muscarinic receptor M1. |
|
T29122 |
VU0090157
|
VU 0090157,VU-0090157 |
|
|
VU0090157, a novel allosteric potentiators of M1 muscarinic receptor, may provide novel treatments for schizophrenia and Alzheimer's disease. |
|
T28168 |
NGX-267
|
AF-267B,AF267B,AF 267B,NGX 267 |
|
|
NGX-267, a muscarinic M1 agonist, is used potentially for the treatment of Xerostomia, Alzheimer's disease and cognitive. |
|
T24333 |
L 687306
|
L687306,L-687306,L687,306,L 687,306,L-687,306 |
|
|
L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors. |
|
T11204 |
ENS-163 phosphate
|
Sandoz ENS 163 phosphate,ENS 213-163,Thiopilocarpine phosphate |
Others
|
|
|
|
T29120 |
VU0029767
|
VU 0029767,VU-0029767 |
|
|
VU0029767 is a selective positive allosteric modulator of M1, a member of the muscarinic acetylcholine family of GPCRs (mAChRs). VU0029767 increases potency and efficacy of acetylcholine (ACh) at M1. |
|
T26604 |
Alvameline Tartrate
|
LU-25-109T,LU 25 109T,LU-25109T,LU 25109T |
|
|
Alvameline Tartrate, a muscarinic M1 receptor agonist and M2/M3 receptor antagonist, is used potentially for treatment of urinary incontinence. |
|
T24577 |
Oxiperomide
|
Peromide |
|
|
Oxiperomide is a dopamine D2 and muscarinic M1 receptor ligand. It also has putative antipsychotic and pro-cognitive potential. |
